CHU de Nice (CHUN)


The Memory Resource and Research Centre (CMRR) of the University Hospital in Nice (CHUN) was officially established on December 19, 2002, following a call from the Department of Health (DHOS) (April 16, 2002 and 16 July 2002). The CMRR is founded on the following four pillars: i) care, ii) teaching, iii) research, and iv) activation and maintenance of professionals’ networks. The research activities of CMRR involve behavioural and affective (mood) disturbances related to dementia. Behavioural disturbances are, in essence, an expression of brain function enabling an individual to adapt to his or her environment. Alzheimer‘s disease is characterised by such behavioural and psychological disturbances, which are referred to by the acronym “BPSD”. BPSD are a focus of interest since they occur very frequently and may play an important role in causing suffering to both people with dementia and their carers.

CMRR in the University Hospital in Nice has an international and national reputation in the research and care of these problems, particularly, the behavioural syndrome of apathy. A particular strength of the CMRR is the development, validation and use of scales and diagnostic criteria for the evaluation of behavioural problems (BPSD) in dementia. Examples include the Neuropsychiatric Inventory (NPI), the Apathy Inventory (AI) diagnostic criteria for apathy. CMMR is also strongly involved in research concerning non-pharmacological treatments for behavioural disturbances in dementia. Non-pharmacological treatments are a key recommendation from various national agencies, for which there is a dearth of welldesigned scientific studies supporting the validity of such techniques. The CMRR of the University Hospital in Nice, with the support of the Department of Health (Direction Générale de la Santé), has recently completed the first randomised-controlled trial evaluating the effect of a specially-trained care team for the management of behavioural disturbances in nursing home (“EHPAD”) residents with dementia in France. Furthermore, CMRR has a strong participation in wider research networks, including the European Alzheimer‘s Disease Consortium (EADC) and the National Alzheimer data basis (BNA). The latter is composed of 327 centres (27 CMRR and 300 memory centres) and is coordinated by Professor Philippe Robert of CMMR, CHUN. Further information for a complete view of the CMMR activities and publications can be found at.

In Dem@Care, CMMR will provide clinical knowledge expertise regarding diagnostic criteria for dementia, behavioural and affective disturbances, the definition and validation of protocols and methodologies for the clinical assessment of people with dementia and of care management and feedback guidelines. CMMR will also have a key role in the overall assessment, from a clinical point of view, of Dem@Care’s performance and effectiveness, and will lead WP8 - Pilots, Evaluation and Clinical Validation, while also being responsible for the running of pilots in France.

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